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BDBM50284234 2-(2,6-Dimethyl-phenyl)-5-(2,2-diphenyl-ethyl)-2,4-dihydro-pyrazol-3-one::CHEMBL267305

SMILES: Cc1cccc(C)c1-n1[nH]c(CC(c2ccccc2)c2ccccc2)cc1=O

InChI Key: InChIKey=UKQIPWMVLBZOJP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50284234   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50284234
PNG
(2-(2,6-Dimethyl-phenyl)-5-(2,2-diphenyl-ethyl)-2,4...)
Show SMILES Cc1cccc(C)c1-n1[nH]c(CC(c2ccccc2)c2ccccc2)cc1=O
Show InChI InChI=1S/C25H24N2O/c1-18-10-9-11-19(2)25(18)27-24(28)17-22(26-27)16-23(20-12-5-3-6-13-20)21-14-7-4-8-15-21/h3-15,17,23,26H,16H2,1-2H3
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Similars

Article
n/an/a 5.08E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition by incubation with [14C]-oleolyl-CoA and intestinal microsomes isolated from choleste...


Bioorg Med Chem Lett 4: 1095-1100 (1994)


Article DOI: 10.1016/S0960-894X(01)80235-3
BindingDB Entry DOI: 10.7270/Q2445MFD
More data for this
Ligand-Target Pair