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BDBM50284654 CHEMBL29725::N-{3-[2'-(1-Methyl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4-oxo-3,4-dihydro-quinazolin-6-yl}-N-pyridin-2-ylmethyl-isonicotinamide

SMILES: Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(cc3c2=O)N(Cc2ccccn2)C(=O)c2ccncc2)cc1

InChI Key: InChIKey=FLSISKDSSXJVNN-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50284654   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50284654
PNG
(CHEMBL29725 | N-{3-[2'-(1-Methyl-1H-tetrazol-5-yl)...)
Show SMILES Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(cc3c2=O)N(Cc2ccccn2)C(=O)c2ccncc2)cc1
Show InChI InChI=1S/C35H27N9O2/c1-42-33(39-40-41-42)30-8-3-2-7-29(30)25-11-9-24(10-12-25)21-43-23-38-32-14-13-28(20-31(32)35(43)46)44(22-27-6-4-5-17-37-27)34(45)26-15-18-36-19-16-26/h2-20,23H,21-22H2,1H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 9.70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against AT1 receptor in rabbit aorta


Bioorg Med Chem Lett 5: 1359-1364 (1995)


Article DOI: 10.1016/0960-894X(95)00224-H
BindingDB Entry DOI: 10.7270/Q2086589
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50284654
PNG
(CHEMBL29725 | N-{3-[2'-(1-Methyl-1H-tetrazol-5-yl)...)
Show SMILES Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(cc3c2=O)N(Cc2ccccn2)C(=O)c2ccncc2)cc1
Show InChI InChI=1S/C35H27N9O2/c1-42-33(39-40-41-42)30-8-3-2-7-29(30)25-11-9-24(10-12-25)21-43-23-38-32-14-13-28(20-31(32)35(43)46)44(22-27-6-4-5-17-37-27)34(45)26-15-18-36-19-16-26/h2-20,23H,21-22H2,1H3
PDB

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PC sid
UniChem

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Article
n/an/a 2.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against AT1 receptor in rat adrenal tissue


Bioorg Med Chem Lett 5: 1359-1364 (1995)


Article DOI: 10.1016/0960-894X(95)00224-H
BindingDB Entry DOI: 10.7270/Q2086589
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50284654
PNG
(CHEMBL29725 | N-{3-[2'-(1-Methyl-1H-tetrazol-5-yl)...)
Show SMILES Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(cc3c2=O)N(Cc2ccccn2)C(=O)c2ccncc2)cc1
Show InChI InChI=1S/C35H27N9O2/c1-42-33(39-40-41-42)30-8-3-2-7-29(30)25-11-9-24(10-12-25)21-43-23-38-32-14-13-28(20-31(32)35(43)46)44(22-27-6-4-5-17-37-27)34(45)26-15-18-36-19-16-26/h2-20,23H,21-22H2,1H3
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antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 4.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against AT1 receptor in human adrenal tissue


Bioorg Med Chem Lett 5: 1359-1364 (1995)


Article DOI: 10.1016/0960-894X(95)00224-H
BindingDB Entry DOI: 10.7270/Q2086589
More data for this
Ligand-Target Pair