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BDBM50286184 (S)-2-{(S)-2-[(S)-2-(2-Hydroxy-5-methoxy-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL542437

SMILES: COc1ccc(O)c(CN[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCSC)C(O)=O)c1

InChI Key: InChIKey=JQHVXZWCTZUNIZ-HHFFYELRNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50286184   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286184
PNG
((S)-2-{(S)-2-[(S)-2-(2-Hydroxy-5-methoxy-benzylami...)
Show SMILES COc1ccc(O)c(CN[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCSC)C(O)=O)c1
Show InChI InChI=1/C27H37N3O6S/c1-17(2)24(28-16-19-15-20(36-3)10-11-23(19)31)26(33)30-22(14-18-8-6-5-7-9-18)25(32)29-21(27(34)35)12-13-37-4/h5-11,15,17,21-22,24,28,31H,12-14,16H2,1-4H3,(H,29,32)(H,30,33)(H,34,35)/t21-,22-,24-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 3.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair