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BDBM50286665 CHEMBL160692::N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5-trimethoxyphenyl)tetrathydrofuran-2-yl)-2-propoxyphenyl]-N-hydroxy-N-methylurea::N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5-trimethoxyphenyl)tetrathydrofuran-2-yl)-2-propoxyphenyl]-N-methylurea

SMILES: CCCOc1c(NC(=O)N(C)O)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1

InChI Key: InChIKey=INTBCVQSXXPZPS-UHFFFAOYNA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50286665   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50286665
PNG
(CHEMBL160692 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)
Show SMILES CCCOc1c(NC(=O)N(C)O)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1/C25H34N2O8/c1-7-10-34-23-17(26-25(28)27(2)29)11-15(12-20(23)30-3)18-8-9-19(35-18)16-13-21(31-4)24(33-6)22(14-16)32-5/h11-14,18-19,29H,7-10H2,1-6H3,(H,26,28)
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PC cid
PC sid
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Similars

Article
n/an/a 514n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement.


Bioorg Med Chem Lett 5: 643-648 (1995)


Article DOI: 10.1016/0960-894X(95)00088-B
BindingDB Entry DOI: 10.7270/Q23778QB
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50286665
PNG
(CHEMBL160692 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)
Show SMILES CCCOc1c(NC(=O)N(C)O)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1/C25H34N2O8/c1-7-10-34-23-17(26-25(28)27(2)29)11-15(12-20(23)30-3)18-8-9-19(35-18)16-13-21(31-4)24(33-6)22(14-16)32-5/h11-14,18-19,29H,7-10H2,1-6H3,(H,26,28)
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PC sid
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Article
n/an/a 17n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells.


Bioorg Med Chem Lett 5: 643-648 (1995)


Article DOI: 10.1016/0960-894X(95)00088-B
BindingDB Entry DOI: 10.7270/Q23778QB
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50286665
PNG
(CHEMBL160692 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)
Show SMILES CCCOc1c(NC(=O)N(C)O)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1/C25H34N2O8/c1-7-10-34-23-17(26-25(28)27(2)29)11-15(12-20(23)30-3)18-8-9-19(35-18)16-13-21(31-4)24(33-6)22(14-16)32-5/h11-14,18-19,29H,7-10H2,1-6H3,(H,26,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 630n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells.


Bioorg Med Chem Lett 5: 643-648 (1995)


Article DOI: 10.1016/0960-894X(95)00088-B
BindingDB Entry DOI: 10.7270/Q23778QB
More data for this
Ligand-Target Pair