BDBM50286819 CHEMBL367463::Pranoprofen::i2-(10H-9-Oxa-1-aza-anthracen-6-yl)-propionic acid

SMILES CC(C(O)=O)c1ccc2Oc3ncccc3Cc2c1

InChI Key InChIKey=TVQZAMVBTVNYLA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50286819   

TargetProstaglandin G/H synthase 1(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50286819(CHEMBL367463 | Pranoprofen | i2-(10H-9-Oxa-1-aza-a...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory activity of the compound against COX-1 from ram seminal vesiclesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
TBA

Curated by ChEMBL
LigandPNGBDBM50286819(CHEMBL367463 | Pranoprofen | i2-(10H-9-Oxa-1-aza-a...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory activity of the compound against COX-1 from ram seminal vesiclesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50286819(CHEMBL367463 | Pranoprofen | i2-(10H-9-Oxa-1-aza-a...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50286819(CHEMBL367463 | Pranoprofen | i2-(10H-9-Oxa-1-aza-a...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50286819(CHEMBL367463 | Pranoprofen | i2-(10H-9-Oxa-1-aza-a...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50286819(CHEMBL367463 | Pranoprofen | i2-(10H-9-Oxa-1-aza-a...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed