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BDBM50287928 1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-yl]-3-(4-chlorophenyl)-(E)-2-propenamide::CHEMBL296693

SMILES: Oc1ccc2C[C@H]3N(CC4CC4)CCC45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\c1ccc(Cl)cc1

InChI Key: InChIKey=RPKXTHDVAPAPMQ-VPJFHMJASA-N

Data: 4 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50287928   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(GUINEA PIG)
BDBM50287928
PNG
(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CCC45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN2O4/c30-20-7-3-17(4-8-20)5-10-24(34)31-21-11-12-29(35)23-15-19-6-9-22(33)26-25(19)28(29,27(21)36-26)13-14-32(23)16-18-1-2-18/h3-10,18,21,23,27,33,35H,1-2,11-16H2,(H,31,34)/b10-5+/t21-,23-,27+,28?,29-/m1/s1
UniProtKB/SwissProt

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Article
0.100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against [3H]- DAMGO labeled mu opioid receptor in guinea-pig brain homogenate.


Bioorg Med Chem Lett 6: 167-172 (1996)


Article DOI: 10.1016/0960-894X(95)00583-F
BindingDB Entry DOI: 10.7270/Q2QJ7H83
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50287928
PNG
(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CCC45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN2O4/c30-20-7-3-17(4-8-20)5-10-24(34)31-21-11-12-29(35)23-15-19-6-9-22(33)26-25(19)28(29,27(21)36-26)13-14-32(23)16-18-1-2-18/h3-10,18,21,23,27,33,35H,1-2,11-16H2,(H,31,34)/b10-5+/t21-,23-,27+,28?,29-/m1/s1
PDB

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UniChem

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Article
0.200n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against [3H]- U-69593 labeled kappa1 opioid receptor in guinea-pig brain homogenate.


Bioorg Med Chem Lett 6: 167-172 (1996)


Article DOI: 10.1016/0960-894X(95)00583-F
BindingDB Entry DOI: 10.7270/Q2QJ7H83
More data for this
Ligand-Target Pair
Opioid receptors; mu/kappa/delta


(Homo sapiens (Human))
BDBM50287928
PNG
(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CCC45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN2O4/c30-20-7-3-17(4-8-20)5-10-24(34)31-21-11-12-29(35)23-15-19-6-9-22(33)26-25(19)28(29,27(21)36-26)13-14-32(23)16-18-1-2-18/h3-10,18,21,23,27,33,35H,1-2,11-16H2,(H,31,34)/b10-5+/t21-,23-,27+,28?,29-/m1/s1
PDB

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KEGG

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Article
5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against [3H]- Cl-DPDPE labeled Opioid receptor delta 1 in guinea-pig brain homogenate.


Bioorg Med Chem Lett 6: 167-172 (1996)


Article DOI: 10.1016/0960-894X(95)00583-F
BindingDB Entry DOI: 10.7270/Q2QJ7H83
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50287928
PNG
(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CCC45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN2O4/c30-20-7-3-17(4-8-20)5-10-24(34)31-21-11-12-29(35)23-15-19-6-9-22(33)26-25(19)28(29,27(21)36-26)13-14-32(23)16-18-1-2-18/h3-10,18,21,23,27,33,35H,1-2,11-16H2,(H,31,34)/b10-5+/t21-,23-,27+,28?,29-/m1/s1
PDB

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PC sid
UniChem

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Article
48n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against [3H]- bremazocine labeled kappa2 opioid receptor in guinea-pig brain homogenate.


Bioorg Med Chem Lett 6: 167-172 (1996)


Article DOI: 10.1016/0960-894X(95)00583-F
BindingDB Entry DOI: 10.7270/Q2QJ7H83
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50287928
PNG
(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CCC45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN2O4/c30-20-7-3-17(4-8-20)5-10-24(34)31-21-11-12-29(35)23-15-19-6-9-22(33)26-25(19)28(29,27(21)36-26)13-14-32(23)16-18-1-2-18/h3-10,18,21,23,27,33,35H,1-2,11-16H2,(H,31,34)/b10-5+/t21-,23-,27+,28?,29-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 2.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against [3H]- U-69593 labeled kappa1 opioid receptor in guinea-pig brain homogenate.


Bioorg Med Chem Lett 6: 167-172 (1996)


Article DOI: 10.1016/0960-894X(95)00583-F
BindingDB Entry DOI: 10.7270/Q2QJ7H83
More data for this
Ligand-Target Pair