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BDBM50289320 5-(4-Methanesulfonyl-phenyl)-6-(3-methoxy-phenyl)-thiazolo[3,2-b][1,2,4]triazole::CHEMBL347378

SMILES: COc1cccc(c1)-c1c(sc2ncnn12)-c1ccc(cc1)S(C)(=O)=O

InChI Key: InChIKey=FGBHTDXMLNCJCI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50289320   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclooxygenase


(Homo sapiens (Human))
BDBM50289320
PNG
(5-(4-Methanesulfonyl-phenyl)-6-(3-methoxy-phenyl)-...)
Show SMILES COc1cccc(c1)-c1c(sc2ncnn12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C18H15N3O3S2/c1-24-14-5-3-4-13(10-14)16-17(25-18-19-11-20-21(16)18)12-6-8-15(9-7-12)26(2,22)23/h3-11H,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells


Bioorg Med Chem Lett 7: 57-62 (1997)


Article DOI: 10.1016/S0960-894X(96)00582-3
BindingDB Entry DOI: 10.7270/Q29W0FG1
More data for this
Ligand-Target Pair
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM50289320
PNG
(5-(4-Methanesulfonyl-phenyl)-6-(3-methoxy-phenyl)-...)
Show SMILES COc1cccc(c1)-c1c(sc2ncnn12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C18H15N3O3S2/c1-24-14-5-3-4-13(10-14)16-17(25-18-19-11-20-21(16)18)12-6-8-15(9-7-12)26(2,22)23/h3-11H,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells


Bioorg Med Chem Lett 7: 57-62 (1997)


Article DOI: 10.1016/S0960-894X(96)00582-3
BindingDB Entry DOI: 10.7270/Q29W0FG1
More data for this
Ligand-Target Pair