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BDBM50290641 (6,7-Dimethoxy-quinazolin-4-yl)-(3-methyl-benzyl)-amine::CHEMBL93173

SMILES: COc1cc2ncnc(NCc3cccc(C)c3)c2cc1OC

InChI Key: InChIKey=QSPYRNNXWWNWNG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50290641   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290641
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(3-methyl-benzyl)-...)
Show SMILES COc1cc2ncnc(NCc3cccc(C)c3)c2cc1OC
Show InChI InChI=1S/C18H19N3O2/c1-12-5-4-6-13(7-12)10-19-18-14-8-16(22-2)17(23-3)9-15(14)20-11-21-18/h4-9,11H,10H2,1-3H3,(H,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of EGF-stimulated proliferation of KB cells in culture


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290641
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(3-methyl-benzyl)-...)
Show SMILES COc1cc2ncnc(NCc3cccc(C)c3)c2cc1OC
Show InChI InChI=1S/C18H19N3O2/c1-12-5-4-6-13(7-12)10-19-18-14-8-16(22-2)17(23-3)9-15(14)20-11-21-18/h4-9,11H,10H2,1-3H3,(H,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 170n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair