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BDBM50290836 (3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-amine::CHEMBL98248

SMILES: COc1cc2nccc(Nc3cccc(Br)c3)c2cc1OC

InChI Key: InChIKey=WCVTXEYTMLUPPQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50290836   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50290836
PNG
((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)
Show SMILES COc1cc2nccc(Nc3cccc(Br)c3)c2cc1OC
Show InChI InChI=1S/C17H15BrN2O2/c1-21-16-9-13-14(20-12-5-3-4-11(18)8-12)6-7-19-15(13)10-17(16)22-2/h3-10H,1-2H3,(H,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
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CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 370n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells


Bioorg Med Chem Lett 7: 2935-2940 (1997)


Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290836
PNG
((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)
Show SMILES COc1cc2nccc(Nc3cccc(Br)c3)c2cc1OC
Show InChI InChI=1S/C17H15BrN2O2/c1-21-16-9-13-14(20-12-5-3-4-11(18)8-12)6-7-19-15(13)10-17(16)22-2/h3-10H,1-2H3,(H,19,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 2.15E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Bioorg Med Chem Lett 7: 2935-2940 (1997)


Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R
More data for this
Ligand-Target Pair