BDBM50291090 (6,7-Dimethoxy-quinazolin-4-yl)-p-tolyl-amine; hydrochloride::CHEMBL1191611::CHEMBL542733::US10548897, Compound 3

SMILES COc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1

InChI Key InChIKey=AHZHKZBDSLBFFP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50291090   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291090((6,7-Dimethoxy-quinazolin-4-yl)-p-tolyl-amine; hyd...)
Affinity DataIC50:  250nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291090((6,7-Dimethoxy-quinazolin-4-yl)-p-tolyl-amine; hyd...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
In DepthDetails Article
TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM50291090((6,7-Dimethoxy-quinazolin-4-yl)-p-tolyl-amine; hyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM50291090((6,7-Dimethoxy-quinazolin-4-yl)-p-tolyl-amine; hyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate by scintillation counting in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM50291090((6,7-Dimethoxy-quinazolin-4-yl)-p-tolyl-amine; hyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:inhibition of human recombinant CDK5/p25 using histone H1 as substrate by scintillation counting in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM50291090((6,7-Dimethoxy-quinazolin-4-yl)-p-tolyl-amine; hyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant GST-fused CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed