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BDBM50292726 1-benzyl-5-((5-chloro-2-hydroxyphenylamino)methylene)-4-methyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile::CHEMBL473533

SMILES: CC1=C(C#N)C(=O)N(Cc2ccccc2)C(=O)C1=CNc1cc(Cl)ccc1O

InChI Key: InChIKey=PQHTVDQCYGKSDR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50292726   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50292726
PNG
(1-benzyl-5-((5-chloro-2-hydroxyphenylamino)methyle...)
Show SMILES CC1=C(C#N)C(=O)N(Cc2ccccc2)C(=O)C1=CNc1cc(Cl)ccc1O
Show InChI InChI=1S/C21H16ClN3O3/c1-13-16(10-23)20(27)25(12-14-5-3-2-4-6-14)21(28)17(13)11-24-18-9-15(22)7-8-19(18)26/h2-9,11,24,26H,12H2,1H3
PDB
MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a 5.00E+4n/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Inhibition of Met in HGF-stimulated human B5/589 cells by electrochemiluminescent two-site immunoassay


J Med Chem 52: 943-51 (2009)


Article DOI: 10.1021/jm800791f
BindingDB Entry DOI: 10.7270/Q2CN73XK
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50292726
PNG
(1-benzyl-5-((5-chloro-2-hydroxyphenylamino)methyle...)
Show SMILES CC1=C(C#N)C(=O)N(Cc2ccccc2)C(=O)C1=CNc1cc(Cl)ccc1O
Show InChI InChI=1S/C21H16ClN3O3/c1-13-16(10-23)20(27)25(12-14-5-3-2-4-6-14)21(28)17(13)11-24-18-9-15(22)7-8-19(18)26/h2-9,11,24,26H,12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 4.30E+4n/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Inhibition of human Met by electrochemiluminescent two-site immunoassay


J Med Chem 52: 943-51 (2009)


Article DOI: 10.1021/jm800791f
BindingDB Entry DOI: 10.7270/Q2CN73XK
More data for this
Ligand-Target Pair