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BDBM50293003 2-amino-4-(naphthalen-1-yl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile::CHEMBL473328

SMILES: N=C1OC2=C(C(C1C#N)c1cccc3ccccc13)C(=O)CC(C2)c1ccccc1

InChI Key: InChIKey=YOZFEKPPAGCENU-UHFFFAOYNA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293003   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50293003
PNG
(2-amino-4-(naphthalen-1-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1cccc3ccccc13)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(20-12-6-10-17-9-4-5-11-19(17)20)25-22(29)13-18(14-23(25)30-26(21)28)16-7-2-1-3-8-16/h1-12,18,21,24,28H,13-14H2
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50293003
PNG
(2-amino-4-(naphthalen-1-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1cccc3ccccc13)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(20-12-6-10-17-9-4-5-11-19(17)20)25-22(29)13-18(14-23(25)30-26(21)28)16-7-2-1-3-8-16/h1-12,18,21,24,28H,13-14H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50293003
PNG
(2-amino-4-(naphthalen-1-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1cccc3ccccc13)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(20-12-6-10-17-9-4-5-11-19(17)20)25-22(29)13-18(14-23(25)30-26(21)28)16-7-2-1-3-8-16/h1-12,18,21,24,28H,13-14H2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair