BDBM50293545 1-(3-(5-(4-(dimethylcarbamoyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)-3-(2-phenoxyphenyl)urea::CHEMBL558347

SMILES CN(C)C(=O)c1ccc(cc1)-c1cnc2[nH]cc(-c3cccc(NC(=O)Nc4ccccc4Oc4ccccc4)c3)c2c1

InChI Key InChIKey=AZSLBPJZDBNJAM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50293545   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293545(1-(3-(5-(4-(dimethylcarbamoyl)phenyl)-1H-pyrrolo[2...)
Affinity DataIC50:  128nMAssay Description:Inhibition of IGF1-induced human IGF1R phosphorylation expressed in mouse NIH-3T3 cells treated 2 hrs prior to IGF1 challenge by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293545(1-(3-(5-(4-(dimethylcarbamoyl)phenyl)-1H-pyrrolo[2...)
Affinity DataIC50:  31nMAssay Description:Inhibition of GST-tagged human IGF1R expressed in Sf9-baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed