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BDBM50293549 1-(3-(5-(3-(dimethylcarbamoyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)-3-(2-(phenylamino)phenyl)urea::CHEMBL555675

SMILES: CN(C)C(=O)c1cccc(c1)-c1cnc2[nH]cc(-c3cccc(NC(=O)Nc4ccccc4Nc4ccccc4)c3)c2c1

InChI Key: InChIKey=QFXXYRAOPMHEAF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50293549   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50293549
PNG
(1-(3-(5-(3-(dimethylcarbamoyl)phenyl)-1H-pyrrolo[2...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cnc2[nH]cc(-c3cccc(NC(=O)Nc4ccccc4Nc4ccccc4)c3)c2c1
Show InChI InChI=1S/C35H30N6O2/c1-41(2)34(42)25-12-8-10-23(18-25)26-20-29-30(22-37-33(29)36-21-26)24-11-9-15-28(19-24)39-35(43)40-32-17-7-6-16-31(32)38-27-13-4-3-5-14-27/h3-22,38H,1-2H3,(H,36,37)(H2,39,40,43)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 407n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R phosphorylation expressed in mouse NIH-3T3 cells treated 2 hrs prior to IGF1 challenge by DELFIA


Bioorg Med Chem Lett 19: 3136-40 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.110
BindingDB Entry DOI: 10.7270/Q2DV1KSP
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50293549
PNG
(1-(3-(5-(3-(dimethylcarbamoyl)phenyl)-1H-pyrrolo[2...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cnc2[nH]cc(-c3cccc(NC(=O)Nc4ccccc4Nc4ccccc4)c3)c2c1
Show InChI InChI=1S/C35H30N6O2/c1-41(2)34(42)25-12-8-10-23(18-25)26-20-29-30(22-37-33(29)36-21-26)24-11-9-15-28(19-24)39-35(43)40-32-17-7-6-16-31(32)38-27-13-4-3-5-14-27/h3-22,38H,1-2H3,(H,36,37)(H2,39,40,43)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 39n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human IGF1R expressed in Sf9-baculovirus system


Bioorg Med Chem Lett 19: 3136-40 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.110
BindingDB Entry DOI: 10.7270/Q2DV1KSP
More data for this
Ligand-Target Pair