BDBM50293555 1-phenyl-3-(3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)urea::CHEMBL550273

SMILES O=C(Nc1ccccc1)Nc1cccc(c1)-c1c[nH]c2ncc(cc12)-c1ccccc1

InChI Key InChIKey=HYHNNPKOTNCPJU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50293555   

TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293555(1-phenyl-3-(3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3...)
Affinity DataIC50:  1.30E+3nMAssay Description:Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293555(1-phenyl-3-(3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3...)
Affinity DataIC50:  749nMAssay Description:Inhibition of GST-tagged human IGF1R expressed in Sf9-baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293555(1-phenyl-3-(3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human N-terminal His-GST-TEV-fused RIP1 kinase domain (1 to 375) autophosphorylation expressed in baculovirus infected insect Sf9 cells...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293555(1-phenyl-3-(3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3...)
Affinity DataIC50:  600nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as prevention of TNFalpha/zVAD.fmk-induced necrotic cell death preincubated for 30 to 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed