BDBM50293743 CHEMBL556667::N-(3-chlorophenyl)picolinamide::cid_836002

SMILES c1ccnc(c1)C(=O)Nc2cccc(c2)Cl

InChI Key InChIKey=SUYUTNCKIOLMAJ-UHFFFAOYSA-N

Data  14 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50293743   

TargetMetabotropic glutamate receptor 4(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  290nMAssay Description:Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium fluxMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/26/2010
Entry Details Article
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TargetMetabotropic glutamate receptor 4 [Q124R](Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  295nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/5/2011
Entry Details
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TargetMetabotropic glutamate receptor 4(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  330nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptorMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/27/2016
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  377nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/5/2011
Entry Details
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TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  728nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptom...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/5/2011
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  1.09E+3nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/5/2011
Entry Details
Copy BDB DOIPCBioAssayPDB3D Structure (crystal)
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  1.10E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/17/2020
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at human mGlu4 receptor assessed as increase in calcium flux by Fluo-4 AM dye based analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/21/2023
Entry Details
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  1.10E+3nMAssay Description:Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilizationMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/26/2010
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  1.20E+3nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptorMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/27/2016
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetMetabotropic glutamate receptor 6(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  5.36E+3nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/5/2011
Entry Details
Copy BDB DOIPCBioAssay
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TargetMetabotropic glutamate receptor 4 [Q124R](Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  9.84E+3nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptom...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/5/2011
Entry Details
Copy BDB DOIPCBioAssayPDB3D Structure (crystal)
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TargetMetabotropic glutamate receptor 8(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  1.35E+4nMAssay Description:Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/5/2011
Entry Details
Copy BDB DOIPCBioAssay
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TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM50293743(CHEMBL556667 | cid_836002 | N-(3-chlorophenyl)pico...)Copy SMILESCopy InChI

Affinity DataEC50:  2.35E+5nMAssay Description:Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/5/2011
Entry Details
Copy BDB DOIPCBioAssay
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