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BDBM50293934 (S)-5-Chloro-1-(1-cyclopropylethyl)-3-[2,6-dichloro-4-(trifluoromethyl)phenylamino]pyrazin-2(1H)-one::CHEMBL551029

SMILES: C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O

InChI Key: InChIKey=SQKXWTQRMQRCRW-ZETCQYMHSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50293934   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293934
PNG
((S)-5-Chloro-1-(1-cyclopropylethyl)-3-[2,6-dichlor...)
Show SMILES C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C16H13Cl3F3N3O/c1-7(8-2-3-8)25-6-12(19)23-14(15(25)26)24-13-10(17)4-9(5-11(13)18)16(20,21)22/h4-8H,2-3H2,1H3,(H,23,24)/t7-/m0/s1
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Similars

Article
PubMed
n/an/a 7.90n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair