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BDBM50293955 (R)-5-Chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one::CHEMBL565169

SMILES: COc1cc(C)c(Nc2nc(Cl)cn([C@@H](CO)C3CC3)c2=O)cc1C

InChI Key: InChIKey=BGWHXWXUGVBBRJ-YQTOOIBONA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50293955   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293955
PNG
((R)-5-Chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4...)
Show SMILES COc1cc(C)c(Nc2nc(Cl)cn([C@@H](CO)C3CC3)c2=O)cc1C
Show InChI InChI=1/C18H22ClN3O3/c1-10-7-15(25-3)11(2)6-13(10)20-17-18(24)22(8-16(19)21-17)14(9-23)12-4-5-12/h6-8,12,14,23H,4-5,9H2,1-3H3,(H,20,21)/t14-/s2
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Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate by gamma counting


J Med Chem 52: 4173-91 (2009)


Article DOI: 10.1021/jm900301y
BindingDB Entry DOI: 10.7270/Q2G44Q9K
More data for this
Ligand-Target Pair