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BDBM50294447 CHEMBL559280::ethyl 7-(3-(3-chlorobenzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

SMILES: CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(Cl)c2)c1

InChI Key: InChIKey=GJFRNUBRALSFKT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50294447   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))
BDBM50294447
PNG
(CHEMBL559280 | ethyl 7-(3-(3-chlorobenzamido)pheny...)
Show SMILES CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C22H17ClN4O3/c1-2-30-22(29)18-13-25-27-19(9-10-24-20(18)27)14-5-4-8-17(12-14)26-21(28)15-6-3-7-16(23)11-15/h3-13H,2H2,1H3,(H,26,28)
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylation


Bioorg Med Chem Lett 19: 2735-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.129
BindingDB Entry DOI: 10.7270/Q28C9W8N
More data for this
Ligand-Target Pair