BDBM50295478 1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13,16-hexaoxahexadecane::CHEMBL539987

SMILES Cc1ccc2oc(cc(=O)c2c1)-c1ccc(OCCOCCOCCOCCOCCOc2ccc(cc2)-c2cc(=O)c3cc(C)ccc3o2)cc1

InChI Key InChIKey=MJRMGLJQJOXSDU-UHFFFAOYSA-N

Data  2 KI  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50295478   

TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataKi:  190nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells by dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataKi:  200nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataEC50:  111nMAssay Description:Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 assessed as reversal of doxorubicin resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataEC50:  264nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataEC50:  65nMAssay Description:Inhibition of BCRP (unknown origin) transfected in HEK293/R2 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataEC50:  63nMAssay Description:Inhibition of BCRP in human MCF7/MX100 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataEC50:  73nMAssay Description:Reversal of MRP1-mediated doxorubicin-resistance in human 2008/MRP1 cells assessed as reduction of doxorubicin IC50 percent by halfMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataEC50:  73nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring reduction in cell survival afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed