BDBM50295551 CHEMBL564975::N-(2-phenylcyclopropyl)-4-(1H-1,2,3-triazol-1-yl)piperidine-1-carboxamide

SMILES O=C(NC1CC1c1ccccc1)N1CCC(CC1)n1ccnn1

InChI Key InChIKey=DIBROLGRIJOMRQ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50295551   

TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295551(CHEMBL564975 | N-(2-phenylcyclopropyl)-4-(1H-1,2,3...)
Affinity DataIC50:  430nMAssay Description:Inhibition of human sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295551(CHEMBL564975 | N-(2-phenylcyclopropyl)-4-(1H-1,2,3...)
Affinity DataIC50:  290nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295551(CHEMBL564975 | N-(2-phenylcyclopropyl)-4-(1H-1,2,3...)
Affinity DataIC50:  3.62E+3nMAssay Description:Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295551(CHEMBL564975 | N-(2-phenylcyclopropyl)-4-(1H-1,2,3...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human mEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295551(CHEMBL564975 | N-(2-phenylcyclopropyl)-4-(1H-1,2,3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Nav1.5 channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295551(CHEMBL564975 | N-(2-phenylcyclopropyl)-4-(1H-1,2,3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295551(CHEMBL564975 | N-(2-phenylcyclopropyl)-4-(1H-1,2,3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295551(CHEMBL564975 | N-(2-phenylcyclopropyl)-4-(1H-1,2,3...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Cav 1.2 channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295551(CHEMBL564975 | N-(2-phenylcyclopropyl)-4-(1H-1,2,3...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IKr channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295551(CHEMBL564975 | N-(2-phenylcyclopropyl)-4-(1H-1,2,3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed