BDBM50295811 12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-butyl]-6,7,12,13-tetrahyhydro-5,7-dioxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole::CHEMBL564940

SMILES COC(=O)[C@]1(O)Cn2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(C[C@H]1O)c4c23

InChI Key InChIKey=DMECWJSRBVZTGX-DXPJPUQTSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50295811   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50:  300nMAssay Description:Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50:  1nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Zap70-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of SYK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed