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BDBM50296354 CHEMBL549369::N-(5-(3,5-difluorophenylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)benzamide

SMILES: CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CCN(Cc12)S(=O)(=O)c1cc(F)cc(F)c1

InChI Key: InChIKey=FYWUYAPXFLZJIW-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50296354   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50296354
PNG
(CHEMBL549369 | N-(5-(3,5-difluorophenylsulfonyl)-4...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CCN(Cc12)S(=O)(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H26F2N6O3S/c1-30-8-10-31(11-9-30)19-4-2-16(3-5-19)24(33)27-23-21-15-32(7-6-22(21)28-29-23)36(34,35)20-13-17(25)12-18(26)14-20/h2-5,12-14H,6-11,15H2,1H3,(H2,27,28,29,33)
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 3.05E+3n/an/an/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Inhibition for IGF1R-induced S6 ribosomal protein phosphorylation in growth factor-stimulated NHDF


J Med Chem 52: 4981-5004 (2010)


Article DOI: 10.1021/jm9002395
BindingDB Entry DOI: 10.7270/Q2P84CTD
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50296354
PNG
(CHEMBL549369 | N-(5-(3,5-difluorophenylsulfonyl)-4...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CCN(Cc12)S(=O)(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H26F2N6O3S/c1-30-8-10-31(11-9-30)19-4-2-16(3-5-19)24(33)27-23-21-15-32(7-6-22(21)28-29-23)36(34,35)20-13-17(25)12-18(26)14-20/h2-5,12-14H,6-11,15H2,1H3,(H2,27,28,29,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 340n/an/an/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Inhibition of IGF1R in growth factor-stimulated NHDF


J Med Chem 52: 4981-5004 (2010)


Article DOI: 10.1021/jm9002395
BindingDB Entry DOI: 10.7270/Q2P84CTD
More data for this
Ligand-Target Pair