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BDBM50296418 2-(6,9-dimethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(4-fluorophenyl)ethanone::CHEMBL559480

SMILES: Cc1ccc(C)c2c3nnc(SCC(=O)c4ccc(F)cc4)nc3[nH]c12

InChI Key: InChIKey=DQYPWHLGJDKSCZ-UHFFFAOYSA-N

Data: 3 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296418   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carboxypeptidase B


(Helicoverpa zea (Corn earworm moth) (Heliothis zea...)
BDBM50296418
PNG
(2-(6,9-dimethyl-5H-[1,2,4]triazino[5,6-b]indol-3-y...)
Show SMILES Cc1ccc(C)c2c3nnc(SCC(=O)c4ccc(F)cc4)nc3[nH]c12
Show InChI InChI=1S/C19H15FN4OS/c1-10-3-4-11(2)16-15(10)17-18(21-16)22-19(24-23-17)26-9-14(25)12-5-7-13(20)8-6-12/h3-8H,9H2,1-2H3,(H,21,22,24)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
9.00E+3n/an/an/an/an/an/an/an/a



Universitat Aut£noma de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of corn earworm recombinant carboxypeptidase B expressed in Pichia pastoris system


Eur J Med Chem 44: 3266-71 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.034
BindingDB Entry DOI: 10.7270/Q26110C4
More data for this
Ligand-Target Pair
Thrombin-activatable fibrinolysis (TAFI)


(Homo sapiens (Human))
BDBM50296418
PNG
(2-(6,9-dimethyl-5H-[1,2,4]triazino[5,6-b]indol-3-y...)
Show SMILES Cc1ccc(C)c2c3nnc(SCC(=O)c4ccc(F)cc4)nc3[nH]c12
Show InChI InChI=1S/C19H15FN4OS/c1-10-3-4-11(2)16-15(10)17-18(21-16)22-19(24-23-17)26-9-14(25)12-5-7-13(20)8-6-12/h3-8H,9H2,1-2H3,(H,21,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.50E+4n/an/an/an/an/an/an/an/a



Universitat Aut£noma de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carboxypeptidase B expressed in Pichia pastoris system


Eur J Med Chem 44: 3266-71 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.034
BindingDB Entry DOI: 10.7270/Q26110C4
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50296418
PNG
(2-(6,9-dimethyl-5H-[1,2,4]triazino[5,6-b]indol-3-y...)
Show SMILES Cc1ccc(C)c2c3nnc(SCC(=O)c4ccc(F)cc4)nc3[nH]c12
Show InChI InChI=1S/C19H15FN4OS/c1-10-3-4-11(2)16-15(10)17-18(21-16)22-19(24-23-17)26-9-14(25)12-5-7-13(20)8-6-12/h3-8H,9H2,1-2H3,(H,21,22,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
8.63E+4n/an/an/an/an/an/an/an/a



Universitat Aut£noma de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A1


Eur J Med Chem 44: 3266-71 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.034
BindingDB Entry DOI: 10.7270/Q26110C4
More data for this
Ligand-Target Pair