BDBM50296669 3-(2-chloro-7-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one::CHEMBL556293

SMILES Cc1ccc2cc(\C=C\C(=O)c3cccs3)c(Cl)nc2c1

InChI Key InChIKey=PSYPLRBBSDXLSS-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296669   

TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296669(3-(2-chloro-7-methylquinolin-3-yl)-1-(thiophen-2-y...)
Affinity DataIC50: 2.97E+3nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296669(3-(2-chloro-7-methylquinolin-3-yl)-1-(thiophen-2-y...)
Affinity DataKi:  1.72E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296669(3-(2-chloro-7-methylquinolin-3-yl)-1-(thiophen-2-y...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed