BDBM50297341 CHEMBL559414::N,N-Diethyl-3-fluoro-4-(spiro[chromene-2,4'-piperidine]-4-yl)-benzamide

SMILES CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc23)c(F)c1

InChI Key InChIKey=PLQNYRUXMGGNNC-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50297341   

TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50297341(CHEMBL559414 | N,N-Diethyl-3-fluoro-4-(spiro[chrom...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50297341(CHEMBL559414 | N,N-Diethyl-3-fluoro-4-(spiro[chrom...)
Affinity DataIC50:  418nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50297341(CHEMBL559414 | N,N-Diethyl-3-fluoro-4-(spiro[chrom...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of human CYP2D6 by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50297341(CHEMBL559414 | N,N-Diethyl-3-fluoro-4-(spiro[chrom...)
Affinity DataEC50:  980nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed