BindingDB PrimarySearch

BDBM50299148 (S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide::1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-prolinamide::BMS-754807::CHEMBL575448

SMILES: C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(F)nc1

InChI Key: InChIKey=LQVXSNNAFNGRAH-UHFFFAOYSA-N

Data: 21 IC50 1 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 106 hits for monomerid = 50299148
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ephrin type-A receptor 2 [596-900] (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	525	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
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BDNF/NT-3 growth factors receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Broad substrate specificity ATP-binding cassette transporter ABCG2 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.77E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Multidrug resistance-associated protein 1 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase LMTK3 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase A (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase B (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
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MAP kinase-activated protein kinase 2 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	919	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 11 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit gamma (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C alpha type (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C delta type (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C zeta type (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C iota type (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	795	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
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BDNF/NT-3 growth factors receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit alpha (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase CSK (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK2 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	347	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	785	n/a	n/a	n/a	n/a	n/a	n/a
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Macrophage-stimulating protein receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Rat)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a
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BDNF/NT-3 growth factors receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a
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Insulin receptor-related protein (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Nek6 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
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NT-3 growth factor receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 2-beta (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
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Angiopoietin-1 receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Nek7 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK4 (Human)	BDBM50299148 (1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a
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