BDBM50299226 8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1,2-f]purine-2,4(3H,8H)-dione::CHEMBL577156

SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1

InChI Key InChIKey=RCJPZVKYTXAIBI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50299226   

TargetEphrin type-B receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299226(8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299226(8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of EphB4 (unknown origin) transfected in CHO cells using Z'-LYTE TYR-1 peptide as substrate after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299226(8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1...)
Affinity DataIC50: 4.35E+3nMAssay Description:Inhibition of EphB4 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299226(8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1...)
Affinity DataIC50: 4.35E+3nMAssay Description:Inhibition of EphB4 (unknown origin) transfected in CHO cells using [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed