BDBM50299783 4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine::CHEMBL574004

SMILES Fc1cccc(Oc2cccc(F)c2C2CCNCC2)c1

InChI Key InChIKey=IMXJQWVQVSZOKO-UHFFFAOYSA-N

Data  4 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50299783   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]RTI-55 from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataKi:  139nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataKi:  1.04E+3nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  915nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  28nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  137nMAssay Description:Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  498nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed