BDBM50300121 (2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((S)-3,4-dihydroxybutyl)-5-fluoro-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide::CHEMBL572933::US8680132, MI- 219
SMILES CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2)[C@@]11C(=O)Nc2cc(Cl)c(F)cc12)C(=O)NCC[C@H](O)CO
InChI Key InChIKey=UNXQGBMZYKHQCO-NVHWNKAKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50300121
Affinity DataKi: 11nMAssay Description:Binding affinity to recombinant human His-tagged MDM2 (1 to 118 amino acids) using p53-based PMDM6-F as probe after 15 mins by competition assayMore data for this Ligand-Target Pair
Affinity DataKi: 13.1nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Binding affinity to MDM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Binding affinity to recombinant human His-tagged MDM2 (1 to 118 amino acids) using p53-based PMDM6-F as probe after 15 to 30 mins by fluorescence pol...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was determined using an optimized, sensitive and quantitative fluorescence polarization-based (FP-based) ...More data for this Ligand-Target Pair
Affinity DataIC50: 162nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair