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BDBM50300135 (R)-5-Chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(6-methoxy-2,5-dimethylpyridin-3-ylamino)pyrazin-2(1H)-one::CHEMBL575491

SMILES: COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O

InChI Key: InChIKey=WHAZSYWKCSEYRK-YQTOOIBONA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50300135   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50300135
PNG
((R)-5-Chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(6...)
Show SMILES COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O
Show InChI InChI=1/C18H23ClN4O3/c1-10-7-13(11(2)20-17(10)26-4)21-16-18(24)23(8-15(19)22-16)14(9-25-3)12-5-6-12/h7-8,12,14H,5-6,9H2,1-4H3,(H,21,22)/t14-/s2
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MMDB

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Similars

Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenate by binding titration assay


J Med Chem 52: 7653-68 (2009)


Article DOI: 10.1021/jm900716v
BindingDB Entry DOI: 10.7270/Q2CN740W
More data for this
Ligand-Target Pair