BDBM50300709 8-(3-bromophenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL567654

SMILES NC1=NC(C2=NCCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(Br)c1

InChI Key InChIKey=RNTPFGORJAAXJQ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50300709   

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300709(8-(3-bromophenyl)-8-(4-(trifluoromethoxy)phenyl)-2...)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300709(8-(3-bromophenyl)-8-(4-(trifluoromethoxy)phenyl)-2...)
Affinity DataIC50:  4.74E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300709(8-(3-bromophenyl)-8-(4-(trifluoromethoxy)phenyl)-2...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed