BDBM50301364 CHEMBL570380::N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1-phenyl-5-(thiophen-2-yl)-1,2-dihydropyridine-3-carboxamide

SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cc(cn(-c5ccccc5)c4=O)-c4cccs4)nc3)c2cc1OC

InChI Key InChIKey=WZTFASVDMINVIL-UHFFFAOYSA-N

Data  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50301364   

TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301364(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of human PyK2 Y402 autophosphorylation expressed in 293T cells by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301364(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301364(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of human FAK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301364(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in alkaline phosphatase levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301364(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  53nMAssay Description:Inhibition of human Pyk2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301364(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in osteocalcin levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed