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BDBM50301977 2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluoropyridin-2-yloxy)-4-methoxybenzoic acid::CHEMBL570696

SMILES: COc1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1

InChI Key: InChIKey=ZECRCJQWVKMLBY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50301977   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen


(Homo sapiens (Human))
BDBM50301977
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES COc1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H20F2N2O5/c1-33-18-8-9-20(26(31)32)23(12-18)35-25-22(28)13-21(27)24(30-25)34-19-7-3-6-17(11-19)16-5-2-4-15(10-16)14-29/h2-13H,14,29H2,1H3,(H,31,32)
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Article
PubMed
n/an/a 9.40E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301977
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES COc1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H20F2N2O5/c1-33-18-8-9-20(26(31)32)23(12-18)35-25-22(28)13-21(27)24(30-25)34-19-7-3-6-17(11-19)16-5-2-4-15(10-16)14-29/h2-13H,14,29H2,1H3,(H,31,32)
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Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50301977
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES COc1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H20F2N2O5/c1-33-18-8-9-20(26(31)32)23(12-18)35-25-22(28)13-21(27)24(30-25)34-19-7-3-6-17(11-19)16-5-2-4-15(10-16)14-29/h2-13H,14,29H2,1H3,(H,31,32)
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Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of tPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair