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BDBM50303065 3-(6-(4-chlorobenzylamino)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine::CHEMBL569012

SMILES: Nc1nn2cccnc2c1-c1cc(NCc2ccc(Cl)cc2)ncn1

InChI Key: InChIKey=DOIVHRUKMVCXKP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50303065   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50303065
PNG
(3-(6-(4-chlorobenzylamino)pyrimidin-4-yl)pyrazolo[...)
Show SMILES Nc1nn2cccnc2c1-c1cc(NCc2ccc(Cl)cc2)ncn1
Show InChI InChI=1S/C17H14ClN7/c18-12-4-2-11(3-5-12)9-21-14-8-13(22-10-23-14)15-16(19)24-25-7-1-6-20-17(15)25/h1-8,10H,9H2,(H2,19,24)(H,21,22,23)
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Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of JAK2 by radiometric assay


Bioorg Med Chem Lett 19: 6529-33 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.053
BindingDB Entry DOI: 10.7270/Q2SJ1MKQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50303065
PNG
(3-(6-(4-chlorobenzylamino)pyrimidin-4-yl)pyrazolo[...)
Show SMILES Nc1nn2cccnc2c1-c1cc(NCc2ccc(Cl)cc2)ncn1
Show InChI InChI=1S/C17H14ClN7/c18-12-4-2-11(3-5-12)9-21-14-8-13(22-10-23-14)15-16(19)24-25-7-1-6-20-17(15)25/h1-8,10H,9H2,(H2,19,24)(H,21,22,23)
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Article
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of JAK2-mediated STAT5 phosphorylation in GMCSF-stimulated human TF1 cells


Bioorg Med Chem Lett 19: 6529-33 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.053
BindingDB Entry DOI: 10.7270/Q2SJ1MKQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50303065
PNG
(3-(6-(4-chlorobenzylamino)pyrimidin-4-yl)pyrazolo[...)
Show SMILES Nc1nn2cccnc2c1-c1cc(NCc2ccc(Cl)cc2)ncn1
Show InChI InChI=1S/C17H14ClN7/c18-12-4-2-11(3-5-12)9-21-14-8-13(22-10-23-14)15-16(19)24-25-7-1-6-20-17(15)25/h1-8,10H,9H2,(H2,19,24)(H,21,22,23)
PDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of JAK3 by radiometric assay


Bioorg Med Chem Lett 19: 6529-33 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.053
BindingDB Entry DOI: 10.7270/Q2SJ1MKQ
More data for this
Ligand-Target Pair