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BDBM50303079 3-(6-(isopropylamino)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine::CHEMBL568790

SMILES: CC(C)Nc1cc(ncn1)-c1c(N)nn2cccnc12

InChI Key: InChIKey=FORJSACMWZCLAC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50303079   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50303079
PNG
(3-(6-(isopropylamino)pyrimidin-4-yl)pyrazolo[1,5-a...)
Show SMILES CC(C)Nc1cc(ncn1)-c1c(N)nn2cccnc12
Show InChI InChI=1S/C13H15N7/c1-8(2)18-10-6-9(16-7-17-10)11-12(14)19-20-5-3-4-15-13(11)20/h3-8H,1-2H3,(H2,14,19)(H,16,17,18)
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PC sid
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Similars

Article
PubMed
n/an/a 210n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of JAK3 by radiometric assay


Bioorg Med Chem Lett 19: 6529-33 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.053
BindingDB Entry DOI: 10.7270/Q2SJ1MKQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50303079
PNG
(3-(6-(isopropylamino)pyrimidin-4-yl)pyrazolo[1,5-a...)
Show SMILES CC(C)Nc1cc(ncn1)-c1c(N)nn2cccnc12
Show InChI InChI=1S/C13H15N7/c1-8(2)18-10-6-9(16-7-17-10)11-12(14)19-20-5-3-4-15-13(11)20/h3-8H,1-2H3,(H2,14,19)(H,16,17,18)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of JAK2 by radiometric assay


Bioorg Med Chem Lett 19: 6529-33 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.053
BindingDB Entry DOI: 10.7270/Q2SJ1MKQ
More data for this
Ligand-Target Pair