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BDBM50303378 4-bromo-N'-(3-((4-chloro-1H-pyrazol-1-yl)methyl)-4-methoxybenzylidene)benzohydrazide::CHEMBL579075

SMILES: COc1ccc(\C=N\NC(=O)c2ccc(Br)cc2)cc1Cn1cc(Cl)cn1

InChI Key: InChIKey=IDENMZZQOVIJOU-LSFURLLWSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50303378   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cruzipain


(Trypanosoma cruzi)
BDBM50303378
PNG
(4-bromo-N'-(3-((4-chloro-1H-pyrazol-1-yl)methyl)-4...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccc(Br)cc2)cc1Cn1cc(Cl)cn1
Show InChI InChI=1S/C19H16BrClN4O2/c1-27-18-7-2-13(8-15(18)11-25-12-17(21)10-23-25)9-22-24-19(26)14-3-5-16(20)6-4-14/h2-10,12H,11H2,1H3,(H,24,26)/b22-9+
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Tryapanosom cruzi cruzain by Flexstation microplate spectrofluorometry


J Med Chem 53: 37-51 (2010)


Article DOI: 10.1021/jm901070c
BindingDB Entry DOI: 10.7270/Q2ZP466W
More data for this
Ligand-Target Pair