BDBM50303727 (4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL584695

SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F

InChI Key InChIKey=JIBQVJZSWQNHLX-HSZRJFAPSA-N

Data  9 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50303727   

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataEC50:  60nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  1.64E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  560nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  2.71E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  2.32E+4nMAssay Description:Inhibition of human recombinant renin by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataEC50:  20nMAssay Description:Inhibition of BACE1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  2.41E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed