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BDBM50303771 (E/Z)-6,7-Dichloro-3-(4-fluorobenzylidene)indolin-2-one::CHEMBL570186

SMILES: Fc1ccc(\C=C2/C(=O)Nc3c2ccc(Cl)c3Cl)cc1

InChI Key: InChIKey=XJEKZYXNOOALGX-XFFZJAGNSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50303771   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NAD-dependent deacetylase sirtuin 2


(Homo sapiens (Human))
BDBM50303771
PNG
((E/Z)-6,7-Dichloro-3-(4-fluorobenzylidene)indolin-...)
Show SMILES Fc1ccc(\C=C2/C(=O)Nc3c2ccc(Cl)c3Cl)cc1
Show InChI InChI=1S/C15H8Cl2FNO/c16-12-6-5-10-11(15(20)19-14(10)13(12)17)7-8-1-3-9(18)4-2-8/h1-7H,(H,19,20)/b11-7-
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.34E+4n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminally 6X-His-tagged SIRT2 after 4 hrs in presence of NAD+ by fluorescent deacetyalse assay


J Med Chem 53: 1383-6 (2010)


Article DOI: 10.1021/jm901055u
BindingDB Entry DOI: 10.7270/Q2V9891P
More data for this
Ligand-Target Pair