BDBM50304194 CHEMBL594228::N-[4-(Benzo[d]thiazol-2''-yl)-2-(trifluoromethoxy)phenyl]-6'-methoxy-7'-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4'-amine

SMILES COc1cc2c(Nc3ccc(cc3F)-c3nc4ccccc4s3)ncnc2cc1OCCCN1CCN(C)CC1

InChI Key InChIKey=ZEXJBANGHOAHDZ-UHFFFAOYSA-N

Data  8 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50304194   

TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataEC50:  1.30E+4nMAssay Description:Inhibition of VEGFR3 in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of EGFR in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataIC50:  350nMAssay Description:Inhibition of VEGFR3 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of TIE2 in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataIC50:  28nMAssay Description:Inhibition of Aurora-B by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataIC50:  805nMAssay Description:Inhibition of wild type EGF-R by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataIC50:  26nMAssay Description:Inhibition of Aurora-A by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataIC50:  62nMAssay Description:Inhibition of VEGFR2 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataIC50:  29nMAssay Description:Inhibition of TIE2 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of ERBB2 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of PDGFRbeta by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304194(CHEMBL594228 | N-[4-(Benzo[d]thiazol-2''-yl)-2-(tr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Aurora-B in human HCT116 cells by cellular proliferation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed