BDBM50304523 CHEMBL595180::N4-(2,6-Dichlorobenzyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine

SMILES CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(N)n1

InChI Key InChIKey=ICAQZJCLBRKWBG-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50304523   

TargetHistamine H4 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304523(CHEMBL595180 | N4-(2,6-Dichlorobenzyl)-6-(4-methyl...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304523(CHEMBL595180 | N4-(2,6-Dichlorobenzyl)-6-(4-methyl...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]tiotidine from GsalphaS-fused human histamine H2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304523(CHEMBL595180 | N4-(2,6-Dichlorobenzyl)-6-(4-methyl...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in Sf9 cells co-expressing RGS4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed