BindingDB logo
myBDB logout

BDBM50304595 (R,S)-N-[2-Benzoyl-4-(phenylsulfamoyl)phenyl]-2-(4-methylpiperazin-1-yl)-2-phenylacetylamide::CHEMBL595995

SMILES: CN1CCN(CC1)C(C(=O)Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(=O)c1ccccc1)c1ccccc1

InChI Key: InChIKey=YYYKZBOSAIRGPP-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304595   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P-glycoprotein 1


(Homo sapiens (Human))
BDBM50304595
PNG
((R,S)-N-[2-Benzoyl-4-(phenylsulfamoyl)phenyl]-2-(4...)
Show SMILES CN1CCN(CC1)C(C(=O)Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C32H32N4O4S/c1-35-19-21-36(22-20-35)30(24-11-5-2-6-12-24)32(38)33-29-18-17-26(34-41(39,40)27-15-9-4-10-16-27)23-28(29)31(37)25-13-7-3-8-14-25/h2-18,23,30,34H,19-22H2,1H3,(H,33,38)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 890n/an/an/an/a



Philipps-Universit£t Marburg

Curated by ChEMBL


Assay Description
Inhibition of ABCB1 overexpressed in human CCRF-CEM/VCR1000 cell assessed as inhibition of daunomycin efflux after 30 mins by FACS analysis


Bioorg Med Chem 17: 7690-7 (2009)


Article DOI: 10.1016/j.bmc.2009.09.043
BindingDB Entry DOI: 10.7270/Q2319W02
More data for this
Ligand-Target Pair