BDBM50304689 5-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine::CHEMBL594844
SMILES Nc1ncc(cn1)-c1nc(N2CCOCC2)c2sccc2n1
InChI Key InChIKey=OCVPDJPZJKVHFR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50304689
Affinity DataKi: 42nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3Kalpha assessed as reduction in 3,4,5-inositoltriphosphate accumulation after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair