BDBM50304689 5-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine::CHEMBL594844

SMILES Nc1ncc(cn1)-c1nc(N2CCOCC2)c2sccc2n1

InChI Key InChIKey=OCVPDJPZJKVHFR-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50304689   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50304689(5-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimid...)
Affinity DataKi:  42nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50304689(5-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimid...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kalpha assessed as reduction in 3,4,5-inositoltriphosphate accumulation after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50304689(5-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimid...)
Affinity DataIC50:  61nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50304689(5-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimid...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed