BDBM50305851 CHEMBL596273::trans-4-((5-(2-(3-methoxybenzylcarbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid

SMILES COc1cccc(CNC(=O)c2cc(cc(C)n2)-c2nnn(C[C@H]3CC[C@@H](CC3)C(O)=O)n2)c1

InChI Key InChIKey=SMHSNYHGGYVOMD-SAABIXHNSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50305851   

TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305851(CHEMBL596273 | trans-4-((5-(2-(3-methoxybenzylcarb...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of full length human recombinant MMP13 using MCA-Arg-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-Glu-Arg-NH2 as substrate preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305851(CHEMBL596273 | trans-4-((5-(2-(3-methoxybenzylcarb...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305851(CHEMBL596273 | trans-4-((5-(2-(3-methoxybenzylcarb...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP3 (unknown origin) catalytic domain using Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 60 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed