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BDBM50305988 5,6-bis(4-chlorophenyl)-N-(4,4-difluorocyclohexyl)pyrazine-2-carboxamide::CHEMBL606757

SMILES: FC1(F)CCC(CC1)NC(=O)c1cnc(-c2ccc(Cl)cc2)c(n1)-c1ccc(Cl)cc1

InChI Key: InChIKey=ZGTSOVCXRVNEHY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50305988   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50305988
PNG
(5,6-bis(4-chlorophenyl)-N-(4,4-difluorocyclohexyl)...)
Show SMILES FC1(F)CCC(CC1)NC(=O)c1cnc(-c2ccc(Cl)cc2)c(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19Cl2F2N3O/c24-16-5-1-14(2-6-16)20-21(15-3-7-17(25)8-4-15)30-19(13-28-20)22(31)29-18-9-11-23(26,27)12-10-18/h1-8,13,18H,9-12H2,(H,29,31)
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Similars

Article
PubMed
n/an/a 5.30n/an/an/an/an/an/a



AstraZeneca R & D M£lndal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor assessed as stimulation of [35S]GTPgammaS binding


Bioorg Med Chem Lett 20: 479-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.125
BindingDB Entry DOI: 10.7270/Q2X34XKB
More data for this
Ligand-Target Pair