BDBM50306130 1'-(6-(1-methyl-3-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-yl)pyridazin-3-yl)-5-(trifluoromethyl)spiro[chroman-2,4'-piperidine]::CHEMBL594051

SMILES Cn1nc(Cc2cccnc2)nc1-c1ccc(nn1)N1CCC2(CC1)CCc1c(O2)cccc1C(F)(F)F

InChI Key InChIKey=BSKAWUIOJVBKRM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50306130   

TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306130(1'-(6-(1-methyl-3-(pyridin-3-ylmethyl)-1H-1,2,4-tr...)
Affinity DataIC50:  65nMAssay Description:Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306130(1'-(6-(1-methyl-3-(pyridin-3-ylmethyl)-1H-1,2,4-tr...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human SCD1 expressed in human 293A cells assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306130(1'-(6-(1-methyl-3-(pyridin-3-ylmethyl)-1H-1,2,4-tr...)
Affinity DataIC50:  4nMAssay Description:Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed