BDBM50307506 1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL599428

SMILES Cn1nc(C(N)=O)c2CCc3cnc(NC4CCN(CC4)C(=O)c4ccccc4)nc3-c12

InChI Key InChIKey=DIASEXMEBNQQHZ-UHFFFAOYSA-N

Data  47 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 47 hits for monomerid = 50307506   

TargetAurora kinase B(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BUB1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  350nMAssay Description:Inhibition of CDK4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK5/P25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  16nMAssay Description:Inhibition of CDK2/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PERKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  670nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 26(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MST4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek6(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NEK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  48nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  226nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of cABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ACK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EEF2KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed