BDBM50308130 4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]-3-thienyl}-carbonyl)amino]cyclopropyl}benzoic Acid::CHEMBL603462

SMILES Cc1sc(C)c(C(=O)NC2(CC2)c2ccc(cc2)C(O)=O)c1Cc1cccc(c1)C(F)(F)F

InChI Key InChIKey=FFFKIGGQAODEPS-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50308130   

TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308130(4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]...)
Affinity DataKi:  0.75nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293-EBNA cells by scintillation counting in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308130(4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]...)
Affinity DataKi:  0.800nM ΔG°:  -12.4kcal/molepH: 6.0 T: 2°CAssay Description:Transfected HEK 293(ebna) cells are maintained in culture, harvested and membranes are prepared by differential centrifugation, following lysis of th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308130(4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]...)
Affinity DataKi: >4.99E+3nMAssay Description:Displacement of [3H]PGD2 from human DP2 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308130(4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]...)
Affinity DataKi: >4.99E+3nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308130(4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]...)
Affinity DataKi: >4.99E+3nMAssay Description:Displacement of [3H]PGD2 from human DP1 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308130(4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]...)
Affinity DataKi: >4.99E+3nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308130(4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]...)
Affinity DataKi: >4.99E+3nMAssay Description:Displacement of [3H]iloprost from human IP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308130(4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]...)
Affinity DataKi: >4.99E+3nMAssay Description:Displacement of [3H]SQ29548 from human TP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308130(4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]...)
Affinity DataKi: >4.99E+3nMAssay Description:Displacement of [3H]PGF2alpha from human FP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308130(4-{1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]...)
Affinity DataKi: >2.91E+4nMAssay Description:Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed