BDBM50308469 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol::CHEMBL3125314::CHEMBL3125315::CHEMBL3125459::CHEMBL589305

SMILES COc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1

InChI Key InChIKey=UEHTWMMZNLKDPS-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50308469   

TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 540nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 820nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 900nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed