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BDBM50308520 CHEMBL603622::cyclophostin

SMILES: CO[P@]1(=O)OC[C@H]2COC(=O)C2=C(C)O1

InChI Key: InChIKey=OMPQJMDGDAAXPE-LRERIDHENA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50308520   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholinesterases


(Homo sapiens (Human))
BDBM50308520
PNG
(CHEMBL603622 | cyclophostin)
Show SMILES CO[P@]1(=O)OC[C@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1/C8H11O6P/c1-5-7-6(3-12-8(7)9)4-13-15(10,11-2)14-5/h6H,3-4H2,1-2H3/t6-,15-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.800n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of AChE by modified Ellman's spectrophotometric method


Bioorg Med Chem 18: 2265-74 (2010)


Article DOI: 10.1016/j.bmc.2010.01.063
BindingDB Entry DOI: 10.7270/Q2RV0NTP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50308520
PNG
(CHEMBL603622 | cyclophostin)
Show SMILES CO[P@]1(=O)OC[C@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1/C8H11O6P/c1-5-7-6(3-12-8(7)9)4-13-15(10,11-2)14-5/h6H,3-4H2,1-2H3/t6-,15-/s2
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair